Insilico pharmacological evaluation of dibenzosuberenone derivatives as antidepressant

نویسندگان

چکیده

A new drug takes a long time and is expensive to introduce.By using insilico design, you can save money. Utilizing computational software, novel Schiff's base Dibenzosuberenone derivative was designed molecular docking studies were performed autodock software. To predict Absorption, Distribution, Metabolism, Excretion, Molecular Properties of derivatives, screening performed. It should be examined how its derivatives interact with specific targets. The successfully identified as targets in this study.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Pharmacological Evaluation of Quinazolinone Derivatives: A Review

In the field of medicinal chemistry, Quinazolinone is a heterocyclic compound having unique place which has medicinal uses as Anticancer, antihypertensive, antihyperlipidemic, antitubercular, CNS depressant, antioxidant, analgesic, antibacterial, anti-inflammatory and antimalarial activity. Quinazolinone based drugs have broadened scope in the field of medicine and Research. Some quinazolinone ...

متن کامل

Design, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists

     New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...

متن کامل

Design, Synthesis and Pharmacological Evaluation of Novel 2-[2-(2-Chlorophenoxy) phenyl]-1,3,4-oxadiazole Derivatives as Benzodiazepine Receptor Agonists

     New derivatives of 2-[2-(2-Chlorophenoxy)phenyl]-1,3,4-oxadiazole as candidates for agonistic effect on benzodiazepine receptors were synthesized. Conformational analysis and superimposition of energy minima conformers of the novel compounds on estazolam, a known benzodiazepine agonist, revealed that the main proposed benzodiazepine pharmacophores were well matched. In pharmacological eval...

متن کامل

Design, Synthesis and Neuropharmacological Evaluation of Thiophene Incorporated Isoxazole Derivatives as Antidepressant and Antianxiety Agents

A series of 5-substituted phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1, 2-oxazoles (2a-l) was synthesized by reacting appropriate chalcones of 2-acetyl thiophene with hydroxylamine hydrochloride in the presence of dry pyridine. The newly synthesized compounds were characterized by IR, HNMR, CNMR and mass spectral data. All the compounds were evaluated for their antidepressant and antianxiety activit...

متن کامل

Synthesis and pharmacological evaluation of novel phenyl sulfonamide derivatives designed as modulators of pulmonary inflammatory response.

In this paper we report the design, synthesis and pharmacological evaluation of a new series of phenyl sulfonamide derivatives 2a-h and 3-8 planned by structural modification on the anti-inflammatory prototype LASSBio-468 (1). Among the synthesized analogues, the tetrafluorophthalimide LASSBio-1439 (2e) stands out showing an in vitro anti-TNF-α effect similar to the standard thalidomide. The re...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: World Journal of Current Medical and Pharmaceutical Research

سال: 2023

ISSN: ['2582-0222']

DOI: https://doi.org/10.37022/wjcmpr.v5i2.257